AI-Driven RNA Synthetic Biology and Therapeutic Development
Our laboratory is developing next-generation RNA synthetic biology platforms empowered by artificial intelligence (AI). By integrating large-scale computational modeling, structural prediction, high-throughput screening, and biological computing strategies, we aim to design programmable functional RNAs and synthetic regulatory circuits capable of environmental sensing, logical computation, and dynamic cellular responses. We are also exploring AI-assisted RNA therapeutic discovery and delivery systems, with the long-term goal of advancing intelligent RNA-based diagnostics, antiviral technologies, and precision medicine applications.
Mechanisms of RNA Post-Transcriptional Homeostasis
Our laboratory is dedicated to understanding the fundamental mechanisms governing RNA post-transcriptional regulation and cellular homeostasis. We focus on the dynamic regulation of RNA processing, modification, degradation, and translation, and investigate how these processes coordinate to maintain cellular function under physiological and stress conditions. By integrating structural biology, biochemistry, and cell biology approaches, we aim to elucidate the molecular and structural basis of RNA-binding proteins and functional RNA complexes, and to uncover how dysregulation of RNA homeostasis contributes to viral infection and human disease.
RNA Homeostasis and Immunity
We are particularly interested in the roles of RNA homeostasis in innate immunity and inflammatory responses, with an emphasis on host recognition and regulation of viral RNAs during infection. Our research focuses on interferon-stimulated genes (ISGs), RNA sensing pathways, and the structural mechanisms underlying antiviral immune responses. Through the study of key RNA-protein complexes and immune regulatory networks, we seek to understand how aberrant RNA homeostasis contributes to viral pathogenesis, inflammatory disorders, and autoimmune diseases, ultimately providing insights for RNA-targeted immunomodulatory therapies and antiviral drug development.